Hyaluronic acid skin boosters in aesthetic medicine: A comparative review of RRS Hyalift 75 syringe, Jalupro SuperHydro, Profhilo, and Monalisa skin in the Egyptian market

Authors

  • Noury Adel Oral and Maxillofacial Surgery Specialist, Cairo, Egypt Author https://orcid.org/0000-0002-0823-3736
  • Amira Gindi Registered Nurse Practitioner, Private Practice, Toronto, Canada Author
  • Jack Kolenda Department of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Canada Author
  • Francisco Llano Specialist in Regenerative Medicine, Specialist in Facial and Body Aesthetics, Private practice, Estado de Mexico, Mexico Author
  • Nenad Stankovic Doctor of Dental Surgery, Specialist of Cosmetology, Private practice, Belgrade, Serbia Author
  • Monica Gindi Internal Medicine doctor, Private Practice, Toronto, Canada Author
  • Jesper Thulesen Oculoplastic surgeon, private practice, Copenhagen, Denmark Author
  • Ida Vega Thulesen Eye Department, Roskilde University Hospital, Roskilde, Denmark Author

Keywords:

Hyaluronic acid, Skin boosters, Biorevitalization, Profhilo, Jalupro SuperHydro, RRS Hyalift, Monalisa Skin

Abstract

Hyaluronic acid (HA) skin boosters have become integral to modern aesthetic medicine as demand grows for minimally invasive, regenerative, and natural looking rejuvenation therapies. This review examines four widely utilized HA based products available in the Egyptian market; RRS Hyalift 75 syringe, Jalupro SuperHydro, Profhilo, and Monalisa Skin, focusing on their biochemical properties, mechanisms of action, clinical evidence, injection protocols, safety, and therapeutic indications. By comparing their composition, rheological characteristics, biostimulatory potential, and longevity, the article provides a clinically relevant guide to optimizing brand specific selection in aesthetic practice. Despite variations in formulation, all reviewed products demonstrate strong safety profiles and efficacy in improving hydration, elasticity, and dermal quality. Continued comparative research, especially head to head trials, is needed to standardize treatment pathways and expand their therapeutic applications.

Author Biographies

  • Noury Adel, Oral and Maxillofacial Surgery Specialist, Cairo, Egypt

    Dr. Noury Adel (MSc, DHM)
    - Oral and Maxillofacial Surgery Specialist
    - KOL & Public Figure
    - International Speaker & Trainer
    - Author & Editor

  • Jack Kolenda, Department of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Canada

    Assistant Professor

  • Francisco Llano, Specialist in Regenerative Medicine, Specialist in Facial and Body Aesthetics, Private practice, Estado de Mexico, Mexico

    Specialist in Regenerative Medicine

References

1. Pino A, Torrecilla J, Alonso JM, Tovito L, Pérez R. Clinical and Biometric Assessment of a Hyaluronic Acid-Based Skin Booster for Face, Neck and Décolleté Rejuvenation: A Prospective Study. J Cosmet Dermatol. 2025 Nov;24(11):e70547.

doi: 10.1111/jocd.70547. PMID: 41243364; PMCID: PMC12620603.

2. Majewska L, Dorosz K, Kijowski J. Facial Skin Density Enhancement Using Hyaluronic Acid-Based Bioactive Hydrogel: Cannula-Assisted Delivery and Ultrasound Evaluation in a Retrospective Controlled Study. Pharmaceutics. 2025 Apr 24;17(5):553.

doi: 10.3390/pharmaceutics17050553.

PMID: 40430846; PMCID: PMC12114969.

3. Goldberg DJ. A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study. J Cosmet Dermatol. 2025 Apr;24(4):e70159.

doi: 10.1111/jocd.70159. PMID: 40243133; PMCID: PMC12004441.

4. Yi KH, Park HJ, Wan J, Suwanchinda A, Koppert E, Kim HJ. Skin-Booster Injection on the Left and Right Sides: Which Side Is More Painful? Dermatol Surg. 2025 May 1;51(9):e52-e56.

doi: 10.1097/DSS.0000000000004670. PMID: 40309988.

5. Parmal S, Subbappa P, Nikam V, Tarwate Y, Barhate K, Wagh S, Gholap AD, Dua K, Singh SK, Parikh D, Shaikh M, Khan TK, Rajput A. Hyaluronic acid based approaches for wound healing: A comprehensive review. Int J Biol Macromol. 2025 May;306(Pt 4):141625.

doi: 10.1016/j.ijbiomac.2025.141625. Epub 2025 Mar 4. PMID: 40049471.

6. Wong V, Manni M. Properties and potentialities of hyaluronic acid and eXcellent Tridimensional Reticulation as a filling agent: a review. Drugs Context. 2025 Aug 13;14.

doi: 10.7573/dic.2025-1-1. PMID: 40832441; PMCID: PMC12360792.

7. Chahine S, Marozzi B, Valle A, Michellini L, Lazzari T. Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study. Cureus. 2025 Aug 13;17(8):e90005.

doi: 10.7759/cureus.90005. PMID: 40951208; PMCID: PMC12431166.

8. Abuyousif HS, Porcello A, Cerrano M, Marques C, Scaletta C, Lourenço K, Abdel-Sayed P, Chemali M, Raffoul W, Hirt-Burri N, Applegate LA, Laurent AE. In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment. Polymers (Basel). 2025 Feb 27;17(5):638.

doi: 10.3390/polym17050638. PMID: 40076130; PMCID: PMC11902836.

9. Leguina-Ruzzi A, Navarro A, Zambrano M. Efficacy and Effectiveness of High Molecular Weight Non-Cross-Linked Hyaluronic Acid Plus Succinic Acid Mesotherapy in Rosacea as Adjunct Therapy. J Cosmet Dermatol. 2025 Oct;24(10):e70484.

doi: 10.1111/jocd.70484. PMID: 41039794; PMCID: PMC12491831.

10. He A, Liu B, Hua Y, Gong Z, Gan F, Zhou Q, Wang S, Zhao X. Clinical Study of Intradermal Injection of Non-Crosslinked Sodium Hyaluronate Combined With Human Epidermal Growth Factor in the Treatment of Skin Barrier Injury in Plateau Area. J Cosmet Dermatol. 2025 Feb;24(2):e16727.

doi: 10.1111/jocd.16727. Epub 2024 Dec 24. PMID: 39717991; PMCID: PMC11837232.

11. El-Sayed MH, Saleh HM, El Zawahry KMA, Mostafa AE. The dermoscopic features of facial aging among Egyptians: A comparative study between males and females. J Cosmet Dermatol. 2019 Dec;18(6):1803-13.

doi: 10.1111/jocd.12913. Epub 2019 Mar 18. PMID: 30884122.

12. Ye H, Sun J, He L, Ai C, Jin W, Abd El-Aty AM. Beneficial effects of proanthocyanidins on skin aging: a review. Front Nutr. 2025 Sep 3;12:1650328.

doi: 10.3389/fnut.2025.1650328. PMID: 40969599; PMCID: PMC12442563.

13. Walker K, Basehore BM, Goyal A, Zito PM. Hyaluronic Acid. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. PMID: 29494047.

14. Zhu H, Zhao N, Guo X. A brief overview of hyaluronic acid research and its applications in cell culture. Biomed Mater. 2025 Jul 24;20(4): 10.1088/1748-605X/adecd1. Published 2025 Jul 24. doi: 10.1088/1748-605X/adecd1. PMID: 40623426.

15. Chylińska N, Maciejczyk M. Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes. Gels. 2025 Apr 9;11(4):281.

doi: 10.3390/gels11040281. PMID: 40277717; PMCID: PMC12026949.

16. Ye H, Zhang R, Zhang C, Xia Y, Jin L. Advances in hyaluronic acid: Bioactivity, complexed biomaterials and biological application: A review. Asian J Surg. 2024 Aug 30:S1015-9584(24)01841-4.

doi: 10.1016/j.asjsur.2024.08.100. Epub ahead of print. PMID: 39217010.

17. Zhou R, Yu M. The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025 Jan;24(1):e16760.

doi: 10.1111/jocd.16760. PMID: 39807700; PMCID: PMC11731322.

18. Deglesne PA, Arroyo R, Ranneva E, Deprez P. In vitro study of RRS HA injectable mesotherapy/biorevitalization product on human skin fibroblasts and its clinical utilization. Clin Cosmet Investig Dermatol. 2016 Feb 23;9:41-53.

doi: 10.2147/CCID.S95108. PMID: 26966384; PMCID: PMC4770068.

19. Adel, N. Low Level laser Therapy & Skin Boosters For Lip Boosting: A Combined Treatment. Egyptian Dental Journal, 2025; 71(2): 1251-6.

doi: 10.21608/edj.2025.357764.3371.

20. El Hawa M, Shahla WA, Fares C, Saade D. Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections. J Cosmet Dermatol. 2025 Jan;24(1):e16624.

doi: 10.1111/jocd.16624. Epub 2024 Nov 15. PMID: 39548357; PMCID: PMC11743251.

21. Adel N, Harhash T, Abdallah N. Evaluation of Non-cross-linked Hyaluronic Acid on Oral Wound Healing After Diode Laser and Scalpel Incisions. Plast Reconstr Surg Glob Open. 2025 May 6;13(5):e6836.

doi: 10.1097/GOX.0000000000006836. PMID: 40330169; PMCID: PMC12055100.

Downloads

Published

2026-01-06

How to Cite

1.
Adel N, Gindi A, Kolenda J, Llano F, Stankovic N, Gindi M, et al. Hyaluronic acid skin boosters in aesthetic medicine: A comparative review of RRS Hyalift 75 syringe, Jalupro SuperHydro, Profhilo, and Monalisa skin in the Egyptian market. Pak J Med Surg Aesthet [Internet]. 2026 Jan. 6 [cited 2026 Jan. 15];1(3):111-23. Available from: https://www.pjmsa.com/index.php/pjmsa/article/view/40