Plant exosomes products in the Egyptian market: Innovation, regulatory gaps, and scientific controversy

Authors

  • Noury Adel Oral and Maxillofacial Surgery Specialist, Cairo, Egypt Author https://orcid.org/0000-0002-0823-3736
  • Amira Gindi Registered Nurse Practitioner, Toronto, Canada Author
  • Nenad Stankovic Doctor of Dental Surgery, Private practice, Belgrade, Serbia Author
  • Jack Kolenda Department of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Canada Author
  • Monica Gindi Internal Medicine doctor, Toronto, Canada Author

Keywords:

Plant based exosomes, plant exosomes, exosomes, biostimulation, regenerative aesthetics, regenerative medicine, stem cells, PDRN, polynucelotide, salmon DNA, functional aesthetics

Abstract

Plant derived extracellular vesicles (PDEVs), often marketed as plant based exosomes, have gained attention in regenerative medicine and aesthetic dermatology due to their biocompatibility and bioactive cargo. This narrative review critically examines commercially available PDEV based products in the Egyptian market, focusing on their reported composition, proposed mechanisms of action, regulatory status, and current clinical evidence. Products including V-Tech Serum® (Promoitalia, Italy), Rx Elysee Exosome PDRN Ampoule® (Dermafirm, South Korea), Glow Exosome® (Louisderma, France), and ExoLure VISAGE® (Hyalure, Italy) are discussed. Available data suggest potential roles in skin rejuvenation, wound healing, and hair restoration; however, product specific clinical evidence remains limited. Significant gaps persist regarding standardized manufacturing methods, transparency of bioactive components, and regulatory oversight. Future well designed clinical trials and standardized characterization protocols are essential to validate safety, efficacy, and reproducibility of PDEV based therapies in aesthetic and therapeutic dermatology.

Author Biography

  • Noury Adel, Oral and Maxillofacial Surgery Specialist, Cairo, Egypt

    Dr. Noury Adel (MSc, DHM)
    - Oral and Maxillofacial Surgery Specialist
    - KOL & Public Figure
    - International Speaker & Trainer
    - Author & Editor

References

1. Mu N, Li J, Zeng L, You J, Li R, Qin A, Liu X, Yan F, Zhou Z. Plant-Derived Exosome-Like Nanovesicles: Current Progress and Prospects. Int J Nanomedicine. 2023 Sep 5;18:4987-5009.

doi: 10.2147/IJN.S420748.

2. Dad HA, Gu TW, Zhu AQ, Huang LQ, Peng LH. Plant Exosome-like Nanovesicles: Emerging therapeutics and drug delivery nanoplatforms. Mol Ther. 2021 Jan 6;29(1):13-31.

doi: 10.1016/j.ymthe.2020.11.030.

3. Zhang Z, Yu Y, Zhu G, Zeng L, Xu S, Cheng H, Ouyang Z, Chen J, Pathak JL, Wu L, Yu L. The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment. Front Immunol. 2022 Jun 10;13:896745.

doi: 10.3389/fimmu.2022.896745.

4. Rezaie J, Feghhi M, Etemadi T. A review on exosomes application in clinical trials: perspective, questions, and challenges. Cell Commun Signal. 2022 Sep 19;20(1):145.

doi: 10.1186/s12964-022-00959-4.

5. Madhan S, Dhar R, Devi A. Plant-derived exosomes: a green approach for cancer drug delivery. J Mater Chem B. 2024 Feb 28;12(9):2236-2252.

doi: 10.1039/d3tb02752j.

6. Kathait P, Patel PK, Sahu AN. Harnessing exosomes and plant-derived exosomes as nanocarriers for the efficient delivery of plant bioactives. Nanomedicine (Lond). 2024; 19(30): 2679-2697. doi: 10.1080/17435889.2024.2354159.

7. Zheng M, Chavda VP, Vaghela DA, Bezbaruah R, Gogoi NR, Patel K, Kulkarni M, Shen B, Singla RK. Plant-derived exosomes in therapeutic nanomedicine, paving the path toward precision medicine. Phytomedicine. 2024 Dec;135:156087. doi: 10.1016/j.phymed.2024.156087.

8. Hou J, Wei W, Geng Z, Zhang Z, Yang H, Zhang X, Li L, Gao Q. Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide. ACS Appl Bio Mater. 2024 May 20;7(5):3050-3060. doi: 10.1021/acsabm.4c00096.

9. Dutta S, Ghosh S, Rahaman M, Chowdhary SR. Plant-derived Exosomes: Pioneering Breakthroughs in Therapeutics, Targeted Drug Delivery, and Regenerative Medicine. Pharm Nanotechnol. 2025;13(4):804-826.

doi: 10.2174/0122117385305245240424093014.

10. Kalele K, Nyahatkar S, Mirgh D, Muthuswamy R, Adhikari MD, Anand K. Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer. ACS Appl Bio Mater. 2024 Mar 18;7(3):1400-15.

doi: 10.1021/acsabm.3c01243.

11. Dal'Forno-Dini T, Birck MS, Rocha M, Bagatin E. Exploring the reality of exosomes in dermatology. An Bras Dermatol. 2025 Jan-Feb;100(1):121-30. doi: 10.1016/j.abd.2024.09.002.

12. Abraham MT, Wilson J 4th. Exosomes in Facial Plastic Surgery. Facial Plast Surg. 2025 Apr;41(2):274-276.

doi: 10.1055/a-2510-6807. Epub 2025 Jan 20. PMID: 39832778

13. Shah M, Dukharan V, Broughton L, Stegura C, Schur N, Samman L, Schlesinger T. Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update. J Cosmet Dermatol. 2025 Jan;24(1):e16766.

doi: 10.1111/jocd.16766.

14. Majewska L, Dorosz K, Kijowski J. Efficacy of Rose Stem Cell-Derived Exosomes (RSCEs) in Skin Treatment: From Healing to Hyperpigmentation Management: Case Series and Review. J Cosmet Dermatol. 2025 Jan;24(1):e16776. doi: 10.1111/jocd.16776.

15. Abarca YA, Scott-Emuakpor R, Tirth J, Moroz O, Thomas GP, Yateem D, Golbari R, Aphia N, Lysak Y, Narasimhan N, Siddiqui HF. Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. Cureus. 2025 Jan 31;17(1):e78298.

doi: 10.7759/cureus.78298.

16. Chen GY, Fu LL, Ye HP, Cheng P, Feng HC, Yan M. Effects of exosomes from human dental pulp stem cells on the biological behavior of human fibroblasts. Sci Rep. 2025 Jan 7;15(1):1134.

doi: 10.1038/s41598-024-78388-1.

17. Kusnandar MR, Wibowo I, Barlian A. Characterizing Nanoparticle Isolated by Yam Bean (Pachyrhizus erosus) as a Potential Agent for Nanocosmetics: An in vitro and in vivo Approaches. Pharm Nanotechnol. 2025;13(2):341-57.

doi: 10.2174/0122117385279809231221050226.

Downloads

Published

2026-01-06

Issue

Vol. 1 No. 3 (2025): Pakistan Journal of Medical and Surgical Aesthetics

Section

Review articles

License

Copyright (c) 2026 Pakistan Journal of Medical and Surgical Aesthetics

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submission declaration

Authors retain the copyright to their work and grant the 'Pakistan Journal of Medical and Surgical Aesthetics (PJMSA)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.

How to Cite

1.
Adel N, Gindi A, Stankovic N, Kolenda J, Gindi M. Plant exosomes products in the Egyptian market: Innovation, regulatory gaps, and scientific controversy. Pak J Med Surg Aesthet [Internet]. 2026 Jan. 6 [cited 2026 Jan. 15];1(3):95-100. Available from: https://www.pjmsa.com/index.php/pjmsa/article/view/11

Most read articles by the same author(s)