Unlocking the Molecular Canvas: Lasers and Epigenetics

Authors

  • Shehla Shaukat King Edward Medical University/ Mayo Hospital, Lahore Author
  • Zahida Rani King Edward Medical University/ Mayo Hospital, Lahore Author

Keywords:

Molecular Canvas, Lasers and Epigenetics

Author Biographies

  • Shehla Shaukat, King Edward Medical University/ Mayo Hospital, Lahore

    Associate Professor

    Dermatology Department

  • Zahida Rani, King Edward Medical University/ Mayo Hospital, Lahore

    Professor of Dermatology

References

1. Lisa Dal Pozzo, Zhe Xu, Shan Lin, Jida Wang, Ying Wang, Ogbe Susan Enechojo, et al. Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight. Biomedicine & Pharmacotherapy. 2024; 174:116592. https://doi.org/10.1016/j.biopha.2024.116592.

2. Haykal D, Flament F, Mora P, Balooch G, Cartier H. Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care. Int J Dermatol. 2025;64(1):15-27.

3. Haykal D, Will F, Cartier H, Dahan S. Epigenetic Modifications and the Role of Medical Lasers in Enhancing Skin Regeneration. J Cosmet Dermatol. 2025;24(1):e16780.

4. Wang K, Liu H, Hu Q, Wang L, Liu J, Zheng Z. et al. Epigenetic regulation of aging: implications for interventions of aging and diseases. Sig Transduct Target Ther. 2022;7: 374.

https://doi.org/10.1038/s41392-022-01211-8

5. DelaO-Escamilla A, Khalil S, Galadari H, Guida S. Epigenetic Clocks in Skin Aging: From Exposome Drivers to Biomarkers and Therapeutic Interventions. Clin Cosmet Investig Dermatol. 2025;18:3681-94.

6. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.

7. Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327. doi:10.18632/aging.101684.

8. Haykal D. Lasers as Epigenetic Modulators: Reprogramming Skin Biology Toward Regeneration and Longevity – EADV 2025. EMJ Dermatol. 2025;13(1):26-30.

9. Spandau DF, Chen R, Wargo JJ, Rohan CA, Southern D, Zhang A, et al. Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia. J Clin Invest. 2021 Oct 1;131(19):e150972. doi: 10.1172/JCI150972. PMID: 34428179; PMCID: PMC8483749.

10. Benson TA, Hibler BP, Kotliar D, Avram M. Nonablative fractional laser treatment is associated with a decreased risk of subsequent facial keratinocyte carcinoma development. Dermatol Surg. 2023;49(2):149-54.

11. Falckenhayn C, Bienkowska A, Söhle J, Wegner K, Raddatz G, Kristof B, et al. Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin. Front Aging. 2024 Mar 4;4:1258184. doi: 10.3389/fragi.2023.1258184. PMID: 38500495; PMCID: PMC10944877.

12. Quan T. Human skin aging and the anti-aging properties of retinol. Biomolecules. 2023;13(11):1614.

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Published

2026-09-13

Issue

Section

Editorial

How to Cite

1.
Shaukat S, Rani Z. Unlocking the Molecular Canvas: Lasers and Epigenetics. Pak J Med Surg Aesthet [Internet]. 2026 Sep. 13 [cited 2026 Sep. 14];2(2):30-2. Available from: https://www.pjmsa.com/index.php/pjmsa/article/view/59