The Efficacy of Skin Booster Containing Hyaluronic Acid, Glutathione and Salmon-Derived Polydeoxyribonucleotide in Skin Hydration and Brightness: A Case Study

Authors

  • Diah Puspitosari Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author
  • Annisa Sundani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author
  • Nizami Hamada Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author
  • Trustia Rizqandaru Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author
  • Kartika Ruchiatan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author
  • Reti Hindritiani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia Author

Keywords:

cosmetic dermatology, photoaging, skin boosters, skin brightening, skin hydration

Abstract

Skin booster is a biological material that is injected intradermally to improve skin quality. The content of hyaluronic acid (HA), glutathione, and polydeoxyribonucleotide (PDRN) in the skin booster is used to increase skin hydration, brightness, and reduce wrinkles. A 61-year-old woman with photoaging was subjected to a split-face treatment approach. The left cheek received topical therapy, while the right cheek underwent a combination of topical therapy and intradermal injection of a skin booster containing HA, glutathione, and salmon PDRN. This treatment was administered in two sessions with a four-week interval. The results of the corneometry examination showed an increase in hydration (right increase 1.34; left fixed). Additionally, there were improvements in skin brightness observed in both the MASI score (reduced from 7.2 to 6.6) and spectrophotometer measurements (right increase by 3.37; left 2.53). HA works by hydrating the skin through the activation of fibroblasts and stimulation of neocollagenesis. Glutathione can prevent melanin formation by blocking the tyrosinase enzyme and enhancing lighter pigments. PDRN has been shown to reduce melanin production, tyrosinase activity, and certain protein expressions while enhancing specific signaling pathways in melanocytes.

References

1. Macneal P, Hohman MH, Adlard RE. Rhombic Flaps. 1. Ypiranga S, Fonseca R. Hyaluronic acid for skin booster on the face. Dalam: Issa MCA, Tamura B, penyunting. Botulinum toxins, fillers, and related substances. Brazil: Springer; 2019. hlm. 311-9.

2. Watanabe G, Arora S, Sadoughifar R, Batra N. Biorevitalization of the skin with skin boosters: Concepts, variables, and limitations. J Cosmet Dermatol. 2021;20(8):2458-62.

3. Ogilvie A, Mokosch A, Buntrock H, Waibel M, Hund M, Kerscher M, et al. Restylane® skinboosters for the improvement of skin quality results of a consensus meeting. Cosmetic Medicine 2.17 Therapy Focus. 2017:28-34.

4. Hall B. A holistic approach to injectable skinboosters. Journal of Aesthetic Nursing. 2019;8(8):384-8.

5. Rodrigues M, Pandya AG. Hypermelanosis. Dalam: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al; penyunting. Fitzpatrick’s dermatology. Edisi ke-9. New York: Mc Graw Hill; 2019. hlm. 1379-81.

6. Baumann L. Cosmeceuticals and skin care in dermatology. Dalam: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al; penyunting. Fitzpatrick’s dermatology. Edisi ke-9. New York: Mc Graw Hill; 2019. hlm. 3805.

7. Kim T-H, Heo S-Y, Oh G-W, Heo S-J, Jung W-K. Applications of marine organism-derived polydeoxyribonucleotide: Its potential in biomedical engineering. Mar Drugs. 2021;19(6):296.

8. Squadrito F, Bitto A, Irrera N, Pizzino G, Pallio G, Minutoli L, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017;8:224.

9. Yaar M, Gilchrest BA. Aging of skin. Dalam: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, penyunting. Fitzpatrick’s dermatology in general medicine. Edisi ke-8. New York: Mc Graw Hill; 2012. hlm. 1215.

10. Kim Y-J, Kim M-J, Kweon D-K, Lim S-T, Lee S-J. Polydeoxyribonucleotide activates mitochondrial biogenesis but reduces mmp-1 activity and melanin biosynthesis in cultured skin cells. Appl Biochem Biotechnol. 2020;191(2):540-54.

11. Pandel R, Poljšak B, Godic A, Dahmane R. Skin photoaging and the role of antioxidants in its prevention. International Scholarly Research Notices. 2013;2013:930164.

12. Dobos G, Trojahn C, D’Alessandro B, Patwardhan S, Canfield D, Blume-Peytavi U, et al. Effects of intrinsic aging and photodamage on skin dyspigmentation: An explorative study. J Biomed Opt. 2016;21(6):066016.

13. Scharffetter-Kochanek K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L, et al. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol. 2000;35(3):307-16.

14. Laga AC, Murphy GF. The translational basis of human cutaneous photoaging: On models, methods, and meaning. The American Journal of Pathology. 2009;174(2):357-60.

15. Trojahn C, Dobos G, Lichterfeld A, Blume-Peytavi U, Kottner J. Characterizing facial skin ageing in humans: Disentangling extrinsic from intrinsic biological phenomena. BioMed research international. 2015;2015:318586.

16. Clark E, Scerri L. Superficial and medium-depth chemical peels. Clin Dermatol. 2008;26(2):209-18.

17. Rendon MI. Utilizing combination therapy to optimize melasma outcomes. Journal of drugs in dermatology: JDD. 2004;3(5 Suppl):S27-34.

18. Bruce S. Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging. J Drugs Dermatol. 2008;7(2 Suppl):s17-22.

19. Lamia H, Al-Shaimaa Af, Basma M, Nageh A. Evaluation of the efficacy and safety of topical and oral glutathione in treatment of melasma. The Medical Journal of Cairo University. 2018;86(Sept):3083-92.

20. Rathbone M, Christjanson L, Deforge S, Deluca B, Gysbers J, Hindley S, et al. Extracellular purine nucleosides stimulate cell division and morphogenesis: Pathological and physiological implications. Med Hypotheses. 1992;37(4):232-40.

21. Noh TK, Chung BY, Kim SY, Lee MH, Kim MJ, Youn CS, et al. Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster. Int J Mol Sci. 2016;17(9):1448.

22. Kim JH, Kwon T-R, Lee SE, Jang YN, Han HS, Mun SK, et al. Comparative evaluation of the effectiveness of novel hyaluronic acid-polynucleotide complex dermal filler. Sci Rep. 2020;10(1):1-9.

23. Glogau RG. Aesthetic and anatomic analysis of the aging skin. Semin Cutan Med Surg. 1996 Sep;15(3):134-8.

Downloads

Published

2026-06-03

Issue

Vol. 2 No. 1 (2026): January-March

Section

Case Reports

License

Copyright (c) 2026 Pakistan Journal of Medical and Surgical Aesthetics

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submission declaration

Authors retain the copyright to their work and grant the 'Pakistan Journal of Medical and Surgical Aesthetics (PJMSA)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.

How to Cite

1.
Puspitosari D, Sundani A, Hamada N, Rizqandaru T, Ruchiatan K, Hindritiani R. The Efficacy of Skin Booster Containing Hyaluronic Acid, Glutathione and Salmon-Derived Polydeoxyribonucleotide in Skin Hydration and Brightness: A Case Study. Pak J Med Surg Aesthet [Internet]. 2026 Jun. 3 [cited 2026 Jun. 3];2(1):25-9. Available from: https://www.pjmsa.com/index.php/pjmsa/article/view/51