Regenerative aesthetics: The role of stem cells and growth factors in skin rejuvenation
Keywords:
Regenerative aesthetics, Stem cells, Growth factors, PRP, Skin rejuvenationAbstract
Regenerative aesthetics is an emerging paradigm that prioritizes tissue repair and biological rejuvenation over temporary correction of age-related change.1 Stem-cell-based approaches, especially adipose-derived mesenchymal stem cells (ADSCs), can stimulate fibroblast activity, enhance collagen synthesis and support angiogenesis, contributing to improved dermal quality and scar remodeling.2,3 In parallel, growth-factor strategies, e.g. fibroblast or MSC-derived growth-factor formulations and platelet-rich plasma (PRP) have shown clinically meaningful improvements in photoaging and acne scars, particularly when paired with procedures like microneedling or lasers.4,5 Early human data also suggest that topical platelet-derived exosomes can reduce cellular senescence markers and up-regulate extracellular-matrix pathways in aged skin.6 However, translation is limited by variability in preparation protocols, lack of standardization and evolving regulatory guidance for human cell/tissue-based products and exosome-containing products.7,8 This review summarizes current evidence for stem cells, PRP/ growth factors and exosomes in aesthetic practice and highlights future directions for standardized, evidence-based use.9
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