Non-scarring diffuse hair loss in females (18-45 years) of age

Authors

  • Hiba Osama Dermatology Center, Medical City Teaching Hospital, Iraq Author
  • Hayder Al-Hamamy University of Baghdad College of Medicine, Baghdad, Iraq Author

Keywords:

Non-scarring, Diffuse hair loss, Reproductive age

Abstract

Objective: To evaluate the etiology and severity of diffuse non-scarring hair loss in Iraqi females of the reproductive age.

 

Methods: The study is a prospective observational study conducted at the Dermatology Center, Medical City Teaching Hospital, Baghdad, Iraq from March 2021 to September 2022 on a convenient sample of 100 female patients 18-45 years of age who presented with non-scarring diffuse hair loss, decrease in hair density or both for at least 1 year. Full history, general and local scalp examination, hair pulling test, 24 hour hair count, hair density count, Dermatology Life Quality Index and relevant blood investigations were done for all patients.

 

Results: The highest proportion of study patients were in the age < 25 years (46%). Regarding hair pull test, it ranged from 3-20 hairs with a mean of 5.7 hairs and 24 hours hair count shed ranged from 21-700 hairs with a mean of 157.22 hairs/24 hours, hair density in the vertex was 80.47±19.05 hair/cm2, left temporal area 82.23±18.85 hair/cm2 and right temporal area 83.19±18.8 hair/cm2. By investigations Hemoglobin was < 12 G/dl in 45% and serum ferritin was <40µG/l in 54% of patients.

 

Conclusion: The most common diagnosis for hair loss in females of 18-45 years of age was telogen effluvium followed by androgenetic alopecia. Young females (less than 25 years) constituted the majority.

Detailed history, general examination, local scalp examinations and investigations are important in diagnosing, evaluating and finding the etiology of diffuse non-scarring alopecia in young females.

References

1. Aristizabal MA, Bruce AJ, Rogers III RS, Pincelli T. Non-Scarring Alopecia in Females: A Comprehensive Review. EMJ Dermatol [Internet]. 2024 Aug 9 [cited 2025 Jun 9]; Available from: https://www.emjreviews.com/dermatology/article/non-scarring-alopecia-in-females-a-comprehensive-review/

2. Workman K, Piliang M. Approach to the patient with hair loss. J Am Acad Dermatol. 2023 Aug;89(2):S3–8.

3. Jamerson TA, Aguh C. An Approach to Patients with Alopecia. Med Clin North Am. 2021 Jul;105(4):599–610.

4. Kinoshita-Ise M, Fukuyama M, Ohyama M. Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases. J Clin Med. 2023 May 3;12(9):3259.

5. De Berker DAR, Messenger AG, Sinclair RD. Disorders of Hair. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology [Internet]. Malden, Massachusetts, USA: Blackwell Publishing, Inc.; 2004 [cited 2022 Dec 13]. p. 3199–318. Available from: https://onlinelibrary.wiley.com/doi/10.1002/9780470750520.ch63

6. Nguyen B, Tosti A. Alopecia in patients with COVID-19: A systematic review and meta-analysis. JAAD Int. 2022 Jun;7:67-77.

7. Leerunyakul K, Suchonwanit P. Evaluation of Hair Density and Hair Diameter in the Adult Thai Population Using Quantitative Trichoscopic Analysis. BioMed Res Int. 2020 Feb 10;2020:1–6.

8. Li X, Wang X, Wang C, Zhang J, Zhou C. Hair Shedding Evaluation for Alopecia: A Refined Wash Test. Clin Cosmet Investig Dermatol. 2022;15:117.

9. Lalu M, Manickam N, Gopalan K, Vellaisamy SG. Impact on Quality of Life among Females with Diffuse Hair Loss at a Tertiary Care Centre: A Cross-sectional Study. J Clin Diagn Res. 2021;15(10):WC06-WC10.

10. Karakoyun Ö, Ayhan E, Yıldız İ. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single‐Center Experience. J Cosmet Dermatol. 2025 Feb;24(2):e70037.

11. Paichitrojjana A, Paichitrojjana A. Platelet Rich Plasma and Its Use in Hair Regrowth: A Review. Drug Des Devel Ther. 2022 Mar;16:635–45.

12. Zhou Y, Seo J, Tu S, Nanmo A, Kageyama T, Fukuda J. Exosomes for hair growth and regeneration. J Biosci Bioeng. 2024 Jan;137(1):1–8.

13. Veshohilova TP. [Effect of combined use of steroid preparations with pyrroxane on the gonadotropic function of the hypophysis]. Akush Ginekol (Sofiia). 1975 Oct;(10):10-2.

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Published

2025-12-17

How to Cite

1.
Osama H, Al-Hamamy H. Non-scarring diffuse hair loss in females (18-45 years) of age. Pak J Med Surg Aesthet [Internet]. 2025 Dec. 17 [cited 2025 Dec. 18];1(2):60-5. Available from: https://www.pjmsa.com/index.php/pjmsa/article/view/16